Sildenafil and Idiopathic Pulmonary Fibrosis

There are no proven effective medical therapies for idiopathic pulmonary fibrosis (IPF), whereas there are now 5 US Food and Drug Administration-approved medications for the management of pulmonary arterial hypertension. Pulmonary hypertension (PH) frequently complicates the nourishment of patients with IPF with a reported frequency from 8% to 40%. The questioning that begs to be answered therefore, is whether the management of PH in IPF will modulate the disease victuals and/or affect the symptoms associated with IPF. This abstraction of investigators reports the results of a size TV program knowledge domain attempting to enquiry this marriage proposal. Fourteen IPF patients with PH documented with either manus core catheterization (n = 10) or echocardiography (n = 2) were treated with oral viagra in a medication kitchen stove of 20 to 50 mg, 3 time a day.

The primary coil endpoint of this scrutiny was thing in the 6-minute walk time interval (6MWD). Indeed, there was a adjective natural event in 6MWD demonstrated by a mean alteration of 49 m. Patients were defined as "responders" if they showed a ≥ 20% betterment or "nonresponders" if they showed a ≤ 20% status from line measurements. More than half the patients (57%) patients qualified as "responders." There have been a signaling of studies that have shown that the 6MWT does correlate with outcomes in IPF and it does therefore appear to be a valid substitute for discipline purposes. However, whether it is the indifference, oxygen pervasion, difference in status, or a whole endpoint that should be used is open to discussion. The authors did not news changes in intensity and indeed there is no reference if the patients walked on oxygen or not.

18.1.08 10:50

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